     |
国际站：Aldosterone
中文名：醛固酮
CAS：52-39-1
品牌：MedChemExpress (MCE)
存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性：醛固酮是主要的盐皮质激素。醛固酮是一种类固醇激素，由肾上腺皮质的球状带 (ZG) 响应肾素-血管紧张素系统激活 (RAS) 或高钾饮食而合成和分泌。醛固酮活性取决于细胞质/核盐皮质激素受体 (MR) 在细胞水平上的结合和激活[1][2]。
体外：醛固酮（1-1000 nM；24 小时）以剂量依赖性方式抑制血管平滑肌细胞白细胞介素-1β 刺激的亚硝酸盐生成[3]。
体内：醛固酮（1 mg/Kg+1% NaCl；ih；每天一次，持续 3 周）显着增加收缩压 (SBP)、舒张压 (DBP)、左心室收缩压 (LVSP) 和左心室舒张末压 ( LVEDP)[4]。
醛固酮（0.72 mg/kg/天；14 天）导致雄性小鼠血压小幅升高（14 mmHg）[5]< /sup>。
参考文献：
[1]. Nanba K, et al. Aging and Adrenal Aldosterone Production. Hypertension. 2018 Feb;71(2):218-223.
[2]. Cannavo A, et al. Aldosterone and Mineralocorticoid Receptor System in Cardiovascular Physiology and Pathophysiology. Oxid Med Cell Longev. 2018 Sep 19;2018:1204598.
[3]. Ikeda U, et al. Aldosterone inhibits nitric oxide synthesis in rat vascular smooth muscle cells induced by interleukin-1 beta. Eur J Pharmacol. 1995 Jul 18;290(2):69-73.
[4]. Martín-Fernández B, et al. Beneficial effects of proanthocyanidins in the cardiac alterations induced by aldosterone in ratheart through mineralocorticoid receptor blockade. PLoS One. 2014 Oct 29;9(10):e111104.
[5]. Dinh QN, et al. Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor. Brain Res. 2016 Apr 15;1637:146-153.
