Paclitaxel | 紫杉醇

MCE 国际站：Paclitaxel

中文名：紫杉醇

CAS：33069-62-4

品牌：MedChemExpress (MCE)

存储条件：4°C, protect from light

生物活性：紫杉醇是一种天然存在的抗肿瘤剂，可稳定微管蛋白聚合。紫杉醇可引起有丝分裂停滞和凋亡细胞死亡。紫杉醇还诱导自噬^[1][2]。 IC50 和目标：IC50：4 nM（微管）

体外：Paclitaxel (20 nM; 48 hours) 诱导程序性细胞死亡，并在细胞周期的 G2/M 期存在阻滞^[1]。
Paclitaxel (20 nM; 48 hours) 诱导p53^[1] 水平的持续增加。

体内：紫杉醇(1-20 mg/kg; ip; 1次/2天，共5个周期)在低紫杉醇组明显诱导肝转移，对原发肿瘤生长影响不大^[3]。

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研究领域：Cell Cycle/DNA Damage  |  Cytoskeleton  |  Antibody-drug Conjugate/ADC Related  |  Apoptosis  |  Autophagy

作用靶点：Microtubule/Tubulin  |  ADC Cytotoxin  |  Apoptosis  |  Autophagy

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参考文献：
[1]. Choi YH, et al. Paclitaxel-induced growth arrest and apoptosis is associated with the upregulation of the Cdk inhibitor, p21WAF1/CIP1, in human breast cancer cells. oncol Rep. 2012 Dec;28(6):2163-9.

[2]. Dziadyk JM, et al. Paclitaxel-induced apoptosis may occur without a prior G2/M-phase arrest. Anticancer Res. 2004 Jan-Feb;24(1):27-36.

[3]. Li Q, et al. Low doses of paclitaxel enhance liver metastasis of breast cancer cells in the mouse model. FEBS J. 2016 Aug;283(15):2836-52.

[4]. Pan Z, et al. Paclitaxel attenuates Bcl-2 resistance to apoptosis in breast cancer cells through an endoplasmic reticulum-mediated calciumrelease in a dosage dependent manner. Biochem Biophys Res Commun. 2013 Feb 13. pii: S0006-291X(13)00259-3.

[5]. Cadamuro M, et al. Low dose paclitaxel reduces S100A4 nuclear import to inhibit invasion and hematogenous metastasis of cholangiocarcinoma. Cancer Res. 2016 Jun 21.

[6]. Li Q, et al. Low doses of paclitaxel enhance liver metastasis of breast cancer cells in the mouse model. FEBS J. 2016 Jun 16.

[7]. Yilmaz E, et al. Sensory neuron subpopulation-specific dysregulation of intracellular calcium in a rat model of chemotherapy-induced peripheral neuropathy. Neuroscience. 2015 Aug 6;300:210-8.

[8]. Jing C, et al. E7080 enhances the antitumor effects of paclitaxel in anaplastic thyroid cancer. Am J Cancer Res. 2017 Apr 1;7(4):903-912.