- 品牌：博奥龙
- 所属分类：科研试剂 » 其它
- 货号：BDXB0086-100
- 规格：100ml
- 分类：细胞培养与细胞活力
- 计量单位：件
- 最小起订量：1件
- 供货总量：100件
- 发货期限：自买家付款之日起7天内发货
Amphotericin B is a polyene antifungal agent, first isolated by Gold et al from Streptomyces nodosus in 1955. It is an amphoteric compound composed of a hydrophilic polyhydroxyl chain along one side and a lipophilic polyene hydrocarbon chain on the other. Amphotericin B has a high affinity for sterols, primarily ergosterols, of fungal and bacterial cell membranes. After binding to sterols, it forms channels in the membranes, causing small molecules to leak out. Amphotericin B induces K+ leakage which is separate from its lethal actionn, as was demonstrated in humna erythrocytes and is due to the inhibitory effect on the Na+/K+ pump. At sub-lethal concentrations, this agent stimulates ehther the activity of some membrane enzymes or cellular metabolism, in particular stimulation of some cells of the immune system. Amphotericin B is poorly soluble in water and now available in four formulations. The classic amphotericin B deoxycholate formulation has been available since 1960 and is a colloidal suspension of amphotericin B. A bile salt, deoxycholate, is often used as the solubilizing agent.
关键词：两性霉素B（1% DMSO）,供应,科研试剂,其它
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