Catalog Number KMH686
Product Name Recombinant Human ApolipoProtein E/APOE Protein, His Tag
Alias AD2, LPG, APO-E, ApoE4, LDLCQ5, apolipoprotein E
Size 50μg, 100μg
Species Human
Host Mammalian Cells
Source This protein contains the human APOE(Lys19-His317) was fused with the
C-terminal His Tag and expressed in Mammalian cells.
Uniprot Accession
P02649
Purity ≥90% as determined by SDS-PAGE
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Buffer PBS
Predicted Molecular
Weight 32.89kDa
Background
The protein encoded by this gene is a major apoprotein of the chylomicron. It
binds to a specific liver and peripheral cell receptor, and is essential for the
normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps
to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes.
Mutations in this gene result in familial dysbetalipoproteinemia, or type III
hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and
triglycerides are the consequence of impaired clearance of chylomicron and
VLDL remnants. Alternative splicing results in multiple transcript variants.
Storage
Store the product under sterile conditions after opening at -20℃ to -80℃ for 12
months. Avoid repeated freeze-thaw cycles.
Shipping Condition
This product is shipped on ice packs or dry ice.
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