N-(R,S)-alpha-Hydroxyoctadecanoyl-D-erythro-sphing

H2044

N-(R,S)-alpha-Hydroxyoctadecanoyl-D-erythro-sphingosine

synthetic

C₃₆H₇₁N0₄

582

5mg

solid

98+% GC,TLC

N-(R,S)-alpha-Hydroxy-C18:0-D-erythro-ceramide; N-(R,S)-alpha-Hydroxystearoyl-D-erythro-sphingosine

chloroform/methanol/water, 2:1:0.5

-20°C

1. J. M. Hauser, B. M. Buehrer, and R. M. Bell “Role of ceramide in mitogenesis induced by exogenous sphingoid bases.” Journal of Biological Chemistry Vol. 269 pp. 6803, 1994
2. N. S. Radin, “Killing tumours by ceramide-induced apoptosis: a critique of available drugs” Biochemical Journal, Vol. 371 pp. 243-256, 2003
3. N. S. Radin, “Designing anticancer drugs via the achilles heel: ceramide, allylic ketones, and mitochondria” Bioorganic and Medicinal Chemistry, Vol. 11(10) pp. 2123-2142, 2003