N-Heptadecanoyl-sphingosylphosphorylcholine惠诚

H1890

鞘磷脂分析标准品N-Heptadecanoyl-sphingosylphosphorylcholine (mixture of D-erythro and L-threo isomers)

semisynthetic

C₄₀H₈₁N₂O₆P

717

5mg

solid

98+% TLC

N-C17:0-Sphingomyelin

chloroform, ethanol, methanol

-20°C

1. M. Nakane et al. “Lethal forebrain ischemia stimulates sphingomyelin hydrolysis and ceramide generation in the gerbil hippocampus” Neuroscience Letters, Vol. 296 pp. 89-92, 2000
2. T. Kirkegaard et al. “Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology” Nature, Vol. 463 pp. 549-553, 2010
3. M. Schmuth, et al. “Permeability barrier disorder in Niemann-Pick disease: sphingomyelin-ceramide processing required for normal barrier homeostasis” J Invest Dermatol., Vol. 115(3) pp. 459-466, 2000
4. C. St Clair et al. “The probability of neonatal respiratory distress syndrome as a function of gestational age and lecithin/sphingomyelin ratio” Am J Perinatol., Vol. 25(8) pp. 473-480, 2008,