N-C16:0-Cyclopropenylceramide上海惠诚进口

H1887

N-C16:0-Cyclopropenylceramide

synthetic

C₃₅H₆₇NO₃

550

1mg

solid

98+% 1H NMR; HPLC

N-C16:0-CPPC; N-[(1R,2S)-2-Hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]hexadecamideActivity: Dihydroceramide desaturase inhibitor

chloroform, methanol, ethanol

-20°C

1. J. Kraveka et al. “Involvement of Dihydroceramide Desaturase in Cell Cycle Progression in Human Neuroblastoma Cells” Journal of Biological Chemistry, Vol. 282 pp. 16718-16728, 2007
2. C. Bedia et al. “Analogs of the dihydroceramide desaturase inhibitor GT11 modified at the amide function: synthesis and biological activities” Organic Biomolecular Chemistry, Vol. 3 pp. 3707-3712, 2005
3. G. Triola et al. “Synthesis of a Cyclopropene Analogue of Ceramide, a Potent Inhibitor of Dihydroceramide Desaturase” Angewandte Chemie International Edition, Vol. 40(10) pp. 1960-1962, 2001
4. G. Triola et al. “Synthesis of Cyclopropene Analogues of Ceramide and Their Effect on Dihydroceramide Desaturase” Journal of Organic Chemistry, Vol. 68(26) pp. 9924-9932, 2003