δ-三烯生育酚δ-Tocotrienol

The four tocopherols (α, β, δ, and γ) and four tocotrienols (α, β, δ, and γ) are forms of vitamin E, which is known for its antioxidant activity.¹ Tocotrienols are found in high concentrations in palm oil and rice bran. Recent studies observe that tocotrienols may be more effective antioxidants than α-tocopherol, the most abundant form of vitamin E.² At 0.1-10 µM, δ-tocotrienol significantly suppresses H₂O₂-induced cell death of rat striatal neurons and provides protection against S-nitrocysteine-induced cell death and SIN-1 cytotoxicity in a concentration dependant manner.² At concentrations of 10 µM, δ-tocotrienol displays more inhibitory action on adhesiveness of HAECs to U937 monocytic cells, via inhibition of VCAM-1 expression, than α-tocopherol and other tocotrienols at the same concentration.³

1 Kamal-Eldin, A., and Appelqvist, L. The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids 31 671-701 (1996).

2 Osakada, F., Hashino, A., Kume, T., et al. α-Tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons. Neuropharmacology 47 904-915 (2004).

3 Naito, Y., Shimozawa, M., Kuroda, M., et al. Tocotrienols reduce 25-hydroxycholesterol-induced monocyte-endothelial cell interaction by inhibiting the surface expresion of adhesion molecules. Atherosclerosis180 19-25 (2005).