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三尖杉酯碱,Harringtonine

  • 1.00元/1mg
  • 起订量:1 1mg
  • 供货总量:1000 1mg
  • 发布时间:2018-01-28产品供应时间:长期有效

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  • 所属分类:科研试剂 » 分析试剂、标准品
  • 货号:26833-85-2
  • 包装:1mg
  • 级别:分析纯
  • 计量单位:1mg
  • 最小起订量:11mg
  • 供货总量:10001mg
  • 发货期限:自买家付款之日起3天内发货

订购三尖杉酯碱,Harringtonine 产品信息:

Cat. Number
HH0169
Chemical Name
三尖杉酯碱,Harringtonine
CAS Number
[26833-85-2]
Mol. Formula
C28H37NO9
Mol. Weight
531.59
Qty 1
5mg
Qty 2
10mg
Application Notes
≥97%
Synonym
Cephalotaxine, 4-methyl (2R)-2-hydroxy-2-(3-hydroxy-3- methylbutyl)butanedioate (ester) (9CI);Harringtonine
Melting Pt.
73-75°C
Storage condition
-20°C
References

Harringtonine is a cephalotaxine alkaloid originally isolated from Cephalotaxus hainanensis Li; it exhibits antiviral and anticancer activities. Harringtonine immobilizes initiated ribosomes, inhibiting protein translation by binding the A site of the 60 S ribosomal subunit and preventing aminoacyl-tRNA binding. Harringtonine inhibits chikungunya virus infection, suppressing replication, RNA production, and viral protein expression. Alone, harringtonine downregulates production of Mcl-1, increases cleavage of PARP, and inhibits cell growth in acute promyelocytic leukemia (APL) cells. Additionally, this compound improves the efficacy of co-administered chemotherapeutic compounds, further inhibiting proliferation and inducing apoptosis in leukemia cells.

Wu C, Shen H, Xia D. Harringtonine induces apoptosis in NB4 cells through down-regulation of Mcl-1. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2013 Jul;42(4):431-6. PMID: 24022932.

Kaur P, Thiruchelvan M, Lee RC, et al. Inhibition of chikungunya virus replication by harringtonine, a novel antiviral that suppresses viral protein expression. Antimicrob Agents Chemother. 2013 Jan;57(1):155-67. PMID: 23275491.

Ingolia NT, Brar GA, Rouskin S, et al. The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments. Nat Protoc. 2012 Jul 26;7(8):1534-50. PMID: 22836135.

Cai YX, Meng FY, Sun QX, et al. In vitro effect of bortezomib alone or in combination with harringtonine or arsenic trioxide on proliferation and apoptosis of multidrug resistant leukemia cells. Zhonghua Xue Ye Xue Za Zhi. 2008 Nov;29(11):737-40. PMID: 19176009.

Zhang C, Li Y, Ma H, et al. Simultaneous multi-parameter observation of Harringtonine-treating HL-60 cells with both two-photon and confocal laser scanning microscopy. Sci China C Life Sci. 2001 Aug;44(4):383-91. PMID: 18726419.

Fresno M, Jiménez A, Vázquez D. Inhibition of translation in eukaryotic systems by harringtonine. Eur J Biochem. 1977 Jan;72(2):323-30. PMID: 319998.


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三尖杉酯碱,Harringtonine相关产品信息: 

319069  26833-87-4 高三尖杉酯碱 Homoharringtonine
296458 [26833-87-4] Homoharringtonine
288784 [26833-85-2] 三尖杉酯碱,Harringtonine
284143 26833-87-4 HOMOHARRINGTonINE(P)
284142 26833-87-4 HOMOHARRINGTonINE(P)
284141 26833-87-4 HOMOHARRINGTonINE(P)
284040 26833-85-2 HARRINGTonINE(P)
284039 26833-85-2 HARRINGTonINE(P)
284038 26833-85-2 HARRINGTonINE(P)
272351 26833-87-4 HOMOHARRINGTonINE(P)
272350 26833-87-4 HOMOHARRINGTonINE(P)
272349 26833-87-4 HOMOHARRINGTonINE(P)
272260 26833-85-2 HARRINGTonINE(P)
272259 26833-85-2 HARRINGTonINE(P)
272258 26833-85-2 HARRINGTonINE(P)
262009   Homoharringtonine-13C,d3
262008 26833-87-4 Homoharringtonine
258140   4'-Demethyl Homoharringtonine-13C,d3
258139 98599-84-9 4'-Demethyl Homoharringtonine

关键词:三尖杉酯碱,Harringtonine,供应,科研试剂,分析试剂、标准品
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