上海环巴胺 Cyclopamine 4449-51-8 报价-惠诚现货

283852753340347

环巴胺 Cyclopamine

[4449-51-8]

C₂₇H₄₁NO₂

411.63

1mg

(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,1 1bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b- Octadecahydro-3',6',10,11b-tetramethylspiro[9H-benzo [a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol

Soluble to 5 mM in ethanol

Desiccate at -20°C

Inhibitor of hedgehog (Hh) signaling, likely via direct inhibition of Smoothened, the accessory protein to the putative Hh receptor Patched. Anti-cancer and teratogenic in vivo. Depletes stem-like cancer cells in glioblastoma and blocks tumor engraftment.
Purity: >97 %